Desenvolvimento de hidrogel tópico à base de goma guar contendo Lactiplantibacillus plantarum M2

Abstract

The skin acts as a physical barrier, protecting the body against the invasion of environmental microorganisms, whose penetration can cause various pathologies. When this tissue ruptures, skin lesions can occur, leading to infection, and if the wound remains open for more than six weeks, it is considered chronic. This type of injury encourages bacterial proliferation, slowing down the healing process and potentially developing into serious infections. The high costs of treating these epithelial lesions, growing microbial resistance and the side effects of conventional therapies highlight the need for new therapeutic approaches. In this scenario, the bioprospecting of bioactive compounds and biotechnological products is gaining relevance. In this context, this study sought to develop a guar gum-based hydrogel containing Lactiplantibacillus plantarum M2. The methodology employed involved evaluating the efficacy and toxicity of the formulation; dermal toxicity by repeated dose in mice and its hematological, biochemical and histopathological and anti-inflammatory analyses. The results indicated the formulation's in vitro efficiency, absence of irritation, toxicity or hematological and histopathological alterations, as well as its anti-inflammatory effect, reinforcing the formulation's safety and efficacy. Furthermore, these results reinforce the possible proposal to adapt and continue the studies of this promising topical bioproduct, aware of the subsequent and necessary large-scale clinical trials and the evaluation of long-term effects.