Efeitos de um programa de exercícios nos parâmetros clínicos de pacientes com doença renal crônica: um ensaio clínico randomizado

Abstract

Introduction: Chronic kidney disease is a progressive condition that progressively compromises kidney function. To treat it, therapies are suggested that have multiple physical consequences and various clinical complications, impacting the patient's quality of life. In this perspective, non-pharmacological strategies, such as physical exercise, have been identified as promising interventions to promote improvements in overall health, in addition to enhancing treatment outcomes. Objective: To analyze the impact of intradialytic exercise on clinical variables and prognosis of chronic kidney disease in patients undergoing renal replacement therapy. Materials and Methods: This is a randomized, single-center clinical trial with two groups (control and intervention), evaluating the variables of body composition, muscle strength, Kt/V, creatinine, and clearance before and after a 10-week combined training program, comprising 2 weeks of adaptation and 8 weeks of exercise. Results: This study concludes that combined physical exercise during dialysis does not promote statistically significant improvements in dialysis efficiency, BMI, body composition, handgrip strength, or specific markers of kidney disease in a short period. Conclusion: Despite the results found and the limitations observed, the importance of supervised exercise programs is reinforced, recommending the extension of the study time, the increase in the sample size, and the exploration of different protocols to better understand the long-term effects and possible improvements in clinical and functional variables and in the quality of life of chronic kidney patients.