PERSPECTIVAS DO USO DA SALIVA NO DIAGNÓSTICO DE DOENÇAS HIPERGLICEMIANTES

Abstract

Saliva is a useful biological fluid with potential for diagnosis and monitoring of systemic disease because it reflects states of health and disease. Our objective was to evaluate the immunological and biochemical changes in saliva of pediatric patients with cancer, in diabetic patients and to investigate which plant species are most frequently used by diabetics as hypoglycemic. In immunological and biochemical evaluations Cancer patients consisted of 32 children with cancer and 115 children without cancer and the diabetic sample consisted 93 diabetic patients and 49 non diabetic. To assess the ethnopharmacological data 107 diabetics were interviewed using a standard questionnaire and semi-structured interview. The salivary biochemistry was determined by colorimetric assays and The IgA concentration was determined by Enzyme-Linked Immunosorbent Assay - ELISA. DMFT index was employed n dental evaluation. Children with cancer showed an increase in alkaline phosphatase, T4, TSH and glucose and decreased insulin and total IgA. Glucose, urea, calcium, total IgA, IgA anti-mutans IgA anti-insulin and DMFT index was higher in diabetic patients. 16 plant species have been reported for the treatment of diabetes, and pata de vaca , sweet olive, tamarind and insulin were the most used. We conclude the plant species most frequently mentioned have its efficacy as hypoglycemic scientifically attested and saliva can be used to monitor diabetics and cancer patients, which casts new perspectives in the monitoring and treatment of patients with hyperglycemic diseases.