A INFLUÊNCIA DO USO DE ESTATINAS SOBRE A MODULAÇÃO AUTONÔMICA E CAPACIDADE FUNCIONAL DE IDOSOS NA SÍNDROME PÓS COVID-19

Abstract

Introduction: POST-COVID-19 syndrome and its pathophysiological changes can generate dysfunction of the autonomic nervous system (ANS), highlighting the relationship between statins and changes in the levels of angiotensin 2-converting enzymes, LDL-C lipoprotein and total cholesterol. Additionally, functional capacity is an indicator of health, which can be related to autonomic dysfunctions. Objective: To analyze the functional capacity and autonomic modulation responses of elderly people, on the influence of the use of statins on POST-COVID 19 syndrome. Methodology: The project was approved under CEP No. 5,673,910 and after signing the TCLE, the research involved 88 elderly people of both genders, aged between 60 and 85 years old, of both genders, distributed into four groups: Control Group: elderly people without Covid and without using Statins (N=16), Statin Group: elderly people who used Statins (N=14), COVID-19 Group: elderly people who had COVID-19 (N=18) and COVID/Statin Group: elderly people who had COVID-19 and used Statins, (N=40). Data collection took place at the Integrated Care Center for the Elderly (CAISI) and at the Ceuma University bodybuilding gym. Systolic blood pressure (SBP) and diastolic blood pressure (DBP), questionnaires on the use of statins, anthropometric assessment, resting electrocardiogram, and functional capacity test (Sit and Stand 5 times, elbow flexion and timed Up and GO). Results: A significant difference was observed in weight indexes =60.95 kg, and =68.17 kg, and BMI = 25.2 and =27.9 when comparing the Statin Group with the COVID/Statin Group. There was a decrease in SBP and DBP in the Statins + COVID-19 Group compared to the COVID/Statins group. There was a reduction in the RMSSD, indicative of parasympathetic modulation in the Control group in relation to the COVID/Statin group. In VLF (Very Low Frequency (%) there was an increase in the COVID-19 Group in relation to the Control group. There was an increase in LF (%) and LF (n.u.) in the COVID group, and a reduction in HF (%) and HF (n.u. ) in the COVID group. The LF/HF and SD2/SD1 ratios showed an increase in the COVID-19 Group. In the elbow flexion and TUG tests, there was an increase in the Statin Group. Conclusion: Elderly people who contracted COVID-19 demonstrated impaired performance. autonomic modulation, increasing sympathetic modulation and decreasing parasympathetic modulation. The use of Statins appears to play a beneficial role, reducing this impairment. The results suggest that Statins can positively influence functional capacity, especially in elbow flexion and tests. Timed Up and Go. These findings demonstrate relevance to cardiovascular and autonomic health in post-COVID-19 elderly people who use statins.