Efeito da qualidade do sono sobre a modulação autonômica cardíaca, pressão arterial 24 horas e dilatação fluxo mediada da artéria braquial em idosas com síndrome metabólica.

Abstract

Introduction: The Metabolic Syndrome (MS) corresponds to a set of metabolic and hemodynamic changes, often related to advancing age and the gender difference seems to play an important role in its development, being highly prevalent among adult women. Changes in sleep quality also have a positive influence on their development. Aim: to analyze the effect of sleep quality on cardiac autonomic modulation variables, 24-hour blood pressure and brachial artery flow-mediated dilation (FMD) in elderly women with MS. Methods: 30 elderly women were grouped according to the score obtained from the sleep quality questionnaire (PSQI) in: good sleep (SB), bad sleep (SR) and sleep disorder (DS). Anthropometric, biochemical, heart rate variability measurements ambulatory blood pressure monitoring (MAPA) and FMD were collected. In addition, multivariate linear regression models were developed to predict the degree of relationship between the variables. Results: All groups were classified as overweight according to BMI. All participants presented at least three of the five criteria listed for the diagnosis of MS. Cardiac autonomic modulation data showed that the DS group had a loss in total variance and the SR group had the lowest mean of the RR intervals. According to MAPA data, the DS group showed an increase in sleep SBP, total MAP and sleep MAP. Both the SR and DS groups showed changes in FMD. Linear regression models were able to predict for FMD and sleep quality 81% of the changes in these variables based on the model and for SBP 70%. Conclusion: The presence of sleep disorders is related to cardiovascular autonomic dysfunction, endothelial dysfunction, in addition to leading to altered 24-hour pressure lability.