Desenvolvimento de um sensor eletroquímico a base de nanotubo de carbono modificados com ftalocianina de níquel para a determinação do anti-inflamatório diclofenaco

Abstract

The present work presents the development of an electrochemical sensor for the voltammetric determination of the anti-inflammatory diclofenac (DCF) in aqueous solutions on a glassy carbon electrode modified with carbon nanotubes and nickel phthalocyanine (CV/NTC-NiPc). In phosphate-buffered saline solution (pH 7), in the anodic potential scan, the DCF exhibited two oxidation peaks; the latter being used for the other analyzes. A study of the peak current dependence with the DCF concentration in the range 7.9x10-6 - 1.6x10- 5 mol L-1, and detection and quantification limits of 2.4 μmol L-1 and 7,9 μmol L-1, respectively. DCF quantification was analyzed in three different tissue types and shows results within the limits allowed by the Brazilian pharmacopoeia. Recovery tests were performed by adding known concentration values of a DCF standard solution, and the recovery values ranged from 99 to 102%.