INFLAMAÇÃO,SÍNDROME METABÓLICA E MARCADORES DE RISCO CARDIOVASCULAR EM MULHERES COM SÍNDROME DOS OVÁRIOS POLICÍSTICOS

Abstract

BACKGROUND: Polycystic ovary syndrome (PCOS) has been correlated with metabolic syndrome (MS), both with common characteristics regarding the altered lipid profile, obesity, hypertension and the occurrence of cardiovascular diseases. OBJECTIVES: Identify the prevalence of Metabolic Syndrome in women with PCOS and its association with cardiovascular risk markers. METHODS: Cross-sectional, prospective. 191 women between 18 and 42 years were evaluated in the Clinic of Gynecology, University Hospital Maternal-Child Unit of the Federal University of Maranhão, leaving 82 patients with PCOS. The patients underwent a clinical evaluation and screening with detailed history, conducting biochemical and ultrasonographic examinations. To collect data, we used two sheets of protocol, with questionnaires containing identification, weight, height, among other measures, in addition to personal, family, and gynecological history. RESULTS: In women with PCOS, the presence of metabolic syndrome was observed in 21%. In this group, the significant clinical variables were age group from 26 to 32 years (59%), obesity (82%) and acanthosis nigricans (87%). Among the diagnostic criteria for MS, the most common were HDL and waist circumference change (65% and 39%, respectively). Regarding inflammatory markers, only elevated CRP was significant (p value = 0.0030). CONCLUSION: The present study showed a high prevalence of women with MS, mostly young and obese women. Their risk of cardiovascular disease was associated with increased CRP level.