UTILIDADE CLÍNICA DE DIFERENTES MEDIDAS DE LIPÍDIOS E ATIVIDADE INFLAMATÓRIA NA DETECÇÃO DE DOENÇA ARTERIAL CORONARIANA

Abstract

Introduction: Coronary artery disease, is one of the leading causes of mortality in the world. The apolipoproteins appear as a new parameter, more sensitive and specific, and does not require fasting 12:00 for blood collection. The C-reactive protein is the most inflammatory marker studied, because the presence has been detected in inflamed tissue, arteries with atherosclerosis and infarcted cardiac muscle.Objetives: The purpose of this survey was to establish changes in lipid profile and PCR inflammatory marker, as in a group of patients undergoing coronary angiography and corrate them with the severity of the coronary disease.Methods:Cross-sectional study conducted with 292 patients in hemodynamic service of Hospital Universitário Presidente Dutra. After signing the free term, patients responded to a structured questionnaire, checking blood pressure, weight, height, abdominal circumference and hip and then followed by a collection of blood for the performance of biochemical assay. To evaluate the relationship between clinical and laboratory variables and the coronary disease applied the T test of Student and Mann-Whitney, the test of Chi-square and logistic regression to identify predictors of coronary disease.To correlate lipids, apolipoproteins and severity of the coronary disease, it used the one-way ANOVA and Kruskal-Wallis.Results:The group with coronary disease presented age, triglycerides, CT/HDL-c and VLDL-c major and hip circumference, HDL-c less than the group without coronary disease, with statistical significance. Women showed triglycerides, CT/HDL-c and VLDL-c major and hip circumference and weight less than women without coronary disease. Relation between the levels of C-reactive protein and coronary disease, 19.68% of the patients were in the range of low risk, 23,9% with moderate risk and 56.38% with high risk. Conclusion: Were predictors for coronary disease the males, increasing age and VLDL-c and the reduction of Apo A. The higher values of C-reative, triglycerides and VLDL-c and lower levels of HDL-c and Apo A, the greater the severity of the coronary artery disease.