TEDE Communidade: O Programa de Pós-Graduação em Saúde do Adulto - PPGSAD, nômina adotada a partir de maio/2017, anteriormente chamado "Saúde do Adulto e da Criança" e ainda anteriormente de "Materno-Infantil" foi criado em 2005. Desde 2013, o PPGSAD encontra-se instalado no Campus Universitário Dom Delgado, Bacanga, São Luís-Maranhão, e está dotado de estímulos em cumprimento às competências esperadas dos egressos nos campos da pesquisa, ensino e extensão.
https://tedebc.ufma.br/jspui/handle/tede/tede/2031
O Programa de Pós-Graduação em Saúde do Adulto - PPGSAD, nômina adotada a partir de maio/2017, anteriormente chamado "Saúde do Adulto e da Criança" e ainda anteriormente de "Materno-Infantil" foi criado em 2005. Desde 2013, o PPGSAD encontra-se instalado no Campus Universitário Dom Delgado, Bacanga, São Luís-Maranhão, e está dotado de estímulos em cumprimento às competências esperadas dos egressos nos campos da pesquisa, ensino e extensão.2024-03-19T13:14:31ZTradução, adaptação transcultural e análise das propriedades de medida do Psychological Inflexibility in Pain Scale (PIPS) em pacientes brasileiros com dor oncológica
https://tedebc.ufma.br/jspui/handle/tede/tede/5155
Título: Tradução, adaptação transcultural e análise das propriedades de medida do Psychological Inflexibility in Pain Scale (PIPS) em pacientes brasileiros com dor oncológica
Autor: SALES, Sérgio Paulo Mariano de Aguiar
Primeiro orientador: DIBAI FILHO, Almir Vieira
Abstract: Introduction: A recent global estimate indicates that 18 million new cases of cancer
and 9.6 million deaths from cancer occurred worldwide. Many of these cancer cases
progress with pain. The Psychological Inflexibility in Pain Scale (PIPS) was developed
to measure psychological inflexibility in people with chronic pain considering two
domains: “pain avoidance” and “cognitive fusion”. PIPS has already been validated in
several countries, being adapted to Spanish, German, Persian, Japanese and
Chinese. Objective: Translate, cross-culturally adapt and analyze the measurement
properties of the PIPS in Brazilian patients with cancer pain. Methodology: A
translation, cross-cultural adaptation and questionnaire validation study was carried
out in the Pain and Palliative Care sector of the Maranhão Cancer Hospital and
Aldenora Bello Cancer Hospital (São Luís, Maranhão), divided into two phases:
translation and cross-cultural adaptation of the PIPS, and analysis of the measurement
properties of the cross-culturally adapted version. The measurement properties tested
here were: structural validity, construct validity, reliability and internal consistency. In
addition to the PIPS, the following assessment instruments were applied: Pain
Catastrophizing Scale (PCS), Edmonton Symptom Assessment Scale (EASE), Barthel
Scale (BE) and the Hospital Anxiety and Depression Scale (EHAD). Results: The
sample consisted of 122 patients, with the majority of the sample being women
(65.6%), with a mean age of ~49 years, married (50.8%) and with complete primary
education (46.7%). %). It was observed that the majority had uterine cancer (23%) and
leukemia (9.8%). Regarding the evolution of the participants, cases without metastasis
(80.3%) and curative care (95.9%) predominated. Adequate reliability was observed
for both domains, with an ICC of 0.8 for the cognitive fusion domain and 0.95 for the
avoidance domain. There was a correlation with a magnitude greater than 0.30 with
the depression domain of the EHAD and correlations with a magnitude less than 0.30
with the anxiety domain of the EHAD, with the PCS domains and with the Barthel index.
The PIPS cognitive fusion domain did not correlate with the instruments of the present
study (p > 0.05), nor did it correlate with the avoidance domain, both PIPS domains,
with a correlation magnitude of 0.169 (p = 0.079). No ceiling or floor effects were
observed. Conclusion: The Brazilian version of the PIPS is reliable and valid for
measuring avoidance in patients with cancer pain, however, the cognitive fusion
domain is not adequate.
Instituição: Universidade Federal do Maranhão
Tipo do documento: Dissertação2024-02-06T00:00:00ZDesenvolvimento de um modelo animal de câncer de pênis HPV negativo: Potencial efeito do tratamento crônico com composto isolado da Scoparia dulcis L.
https://tedebc.ufma.br/jspui/handle/tede/tede/5126
Título: Desenvolvimento de um modelo animal de câncer de pênis HPV negativo: Potencial efeito do tratamento crônico com composto isolado da Scoparia dulcis L.
Autor: RIBEIRO, Larissa Sousa
Primeiro orientador: SALGADO FILHO, Natalino
Abstract: Introduction: Penile cancer is a serious public health problem in North and Northeast
Brazil. The current classification of the World Health Organization considers that there
are two pathways of penile carcinogenesis, one associated with human papillomavirus
(HPV) and another, less well characterized, independent of HPV, which is speculated
to be induced by chronic inflammation. Furthermore, there are few treatment options
to reduce lesions in this context. The present work aimed to develop an HPV
independent model of penile carcinogenesis, testing the hypothesis that chronic
inflammation induces penile cancer and evaluating the potential effect of treatment with
the isolated compound Cirsitakaoside (Cirsimarina). Methods: Forty male Wistar rats
aged 8 weeks were divided into 6 experimental groups, exposed topically on the glans
penis to saline (Control group), an inflammatory agent (carrageenan, CG), a mutagen
(4-nitroquinoline, 4NQO) and both products. Two groups exposed to GC and 4NQO
also received a natural compound with anti-inflammatory properties, cirsimarine
(0.5mg/Kg and 1.0mg/Kg). The treatment was carried out for 12 weeks. The
macroscopic appearance of the penis and the temperature of the pelvic region were
evaluated using photographic and thermographic techniques. The following organs
were collected: penis, tongue, heart, lung, kidney, spleen, liver, thymus, adrenals,
testes, prostate and adipose tissue and the blood of the animals. The penis was
processed for histological analysis to identify the lesions, and the internal organs were
weighed. Blood samples were used to determine circulating values of total cholesterol,
magnesium and albumin. Results: Macroscopic analysis showed the development of
inflammation in the glans and prepuce of animals exposed to GC and 4NQO, however,
those treated with cirsimarine had a decrease in the inflammatory process. However,
regarding the thermographic analysis, no significant changes were observed. As for
the histological analysis, hyperplasia of the preputial epithelium was observed and one
animal developed penile intraepithelial neoplasia (PeIN), and these alterations were
observed mainly in the groups treated with CG and 4NQO. Animals treated with
cirsimarine did not develop proliferative lesions. Cirsimarine also reduced body weight,
fat mass and total cholesterol, increased thymus and adrenal weights, and reduced
liver, kidney and testicular weights. Conclusions: The administration of CG and 4NQO
resulted in a high incidence of chronic inflammation of the penis and foreskin and a low
incidence of proliferative lesions, supporting the hypothesis that inflammation
promotes penile carcinogenesis, as well as the anti-inflammatory effect of Cirsimarin.
Instituição: Universidade Federal do Maranhão
Tipo do documento: Dissertação; Trabalho sob sigilo. Motivo: Registro de Patente. Data Provável de Liberação: 20/10/2024.2023-07-26T00:00:00ZEfeito do tratamento crônico com derivado da Cannabis Sativa(delta-9- Tetrahidrocanabinol) nos sintomas da menopausa.
https://tedebc.ufma.br/jspui/handle/tede/tede/5107
Título: Efeito do tratamento crônico com derivado da Cannabis Sativa(delta-9- Tetrahidrocanabinol) nos sintomas da menopausa.
Autor: TEIXEIRA, Camila Vitória Pinto
Primeiro orientador: FARIA, Manuel dos Santos
Abstract: The climacteric is characterized by an altered hormonal state and, frequently, by a decrease in
the quality of life, due to the appearance of symptoms that can cause significant discomfort
for some women and one of the main symptoms is hot flushes. Therefore, the scientific
community has been looking for new medicinal alternatives, such as the use of medicinal
plants rich in substances capable of mitigating the effects of the lack of estrogen. Based on
this, the present study aims to evaluate the effect of chronic treatment with the derivative of
Cannabis sativa, cannabidiol, on menopausal symptoms in an animal model. To carry out the
experiment, the animals were divided into 5 groups: Sham operated (SHAM) treated with
mineral oil; Ovariectomized patients treated with mineral oil (OVX VEHIC); Ovariectomized
patients treated with 1mg/kg of estrogen (OVX E2); Ovariectomized patients treated with
10mg/kg of cannabidiol (OVX CBD); Ovariectomized patients treated with a microdose of
estrogen (0.5mg/kg) and cannabidiol (5mg/kg) (OVX CBD E2). During treatment (15 days)
the estrous cycle, body weight and body temperature were measured. At the end, the serum,
hormonal and histological biochemical parameters of the samples were evaluated. The OVX
VEHIC group showed significant changes in body weight, total cholesterol and hormone
markers FSH and estrogen. Furthermore, it was the group that presented the greatest uterine
atrophy among the ovariectomized patients. An increase in the cutaneous caudal temperature
was also observed in relation to the other groups. The OVX E2 group significantly improved
these deleterious effects of estrogen depletion compared to the OVX VEHIC group. The OVX
CBD group showed an increase in total cholesterol, feed intake and body weight and in the
hormone marker estrogen. Uterine atrophy was slightly lower than the vehicle OVX group
and in relation to the estrous cycle, it was observed that there was a permanence of 58.3% in
the estrus phase. Among the ovariectomized groups, the CBD-treated group had the lowest
temperature variation. The OVX CBD E2 group showed significant changes in body weight,
feed intake, adipose tissue weight, total cholesterol and estrogen levels. Regarding uterine
atrophy, this atrophy was significantly reduced compared to all other groups submitted to
ovariectomy and presented cyclicity of 57.14% in the estrus phase. Therefore, it is possible to
conclude that the administration of the association of CBD with estrogen presented favorable
results in relation to the reversal of some common conditions in menopause, such as the
decrease in body weight, reversal of uterine atrophy, decrease in adipose tissue and total
cholesterol and also in relation to hot flush induction was statistically significant when
compared with the SHAM group. Thus, new studies must be carried out to explore the
mechanisms related to these data found in the present study.
Instituição: Universidade Federal do Maranhão
Tipo do documento: Dissertação2023-07-24T00:00:00ZKlotho no câncer : uma revisão sistemática
https://tedebc.ufma.br/jspui/handle/tede/tede/5025
Título: Klotho no câncer : uma revisão sistemática
Autor: COSTA, Jucileide Mota
Primeiro orientador: OLIVEIRA, Rui Miguel Gil da Costa
Abstract: Introduction and objective: The Klotho protein, encoded by the KL gene, is part of
the FGF-Klotho endocrine system and plays a role in the pathophysiology of agerelated
disorders, including cancer. Klotho is considered a tumor suppressor and has potential
for treating cancer. It has been found to reduce the proliferation of cancer cells and
induce apoptosis in several types of cancer. The molecular mechanism underlying the
tumor suppressive effect of Klotho is not well understood. Klotho forms a complex with
FGFRs and is required for the high affinity binding of FGFs to their receptors. It is
expressed in various tissues and organs, with highest levels in the kidney. Klotho
interacts with several members of the Wnt family and may play a role in aging.
Alterations in Wnt signaling are implicated in cancer development and progression.
This dissertation discusses the role of Klotho proteins in various types of cancer and
their potential use as diagnostic and prognostic markers. Methodology: This is a
systematic review, which analyzed articles published between 2012 and 2022,
according to the Preferred Reporting Items for Systematic Reviews and Metaanalyses
(PRISMA). The search strategy was carried out in three databases: PubMed, Scielo
and ScienceDirect, using the keywords "cancer AND Klotho", accessed in April 2023.
The search resulted in 836 articles, 401 of which were duplicates. the inclusion and
exclusion criteria, 26 articles were part of this systematic review. Results: Among the
26 articles selected, 21 dealt with αKlotho, 5 with βKlotho and only 3 with γKlotho, one
article studying α and βKlotho and another studying all three proteins. αKlotho was
found to be consistently associated with improved prognosis and may be useful for
estimating cancer patient survival. αKlotho appears to act as a tumor suppressor and
its down-regulation has been associated with aggressive tumor phenotypes and worse
prognosis. Elevated γKlotho levels are associated with cancer aggressiveness and
poor prognosis, and may be useful in predicting patient survival and response to
therapy. βKlotho shows mixed results. Conclusion: While αKlotho was associated with
a better patient prognosis, γKlotho was associated with increased cancer
aggressiveness, and βKlotho had mixed results. It is essential to accurately identify
tumor subtypes and Klotho expression for maximum applicability of its biological
potential. However, most studies have not yet provided such detailed results and the
clinical use of Klotho will require further studies in the future.
Instituição: Universidade Federal do Maranhão
Tipo do documento: Dissertação2023-07-26T00:00:00Z